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626 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins
CC-647 is a Cereblon modulator
126 Purity (HPLC) >= 95% Solubility DMSO
Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg 626 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
